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GeneSight Genetic Testing

At Greenwich Village Psychiatry in Manhattan, we understand that finding the right medication for depression, anxiety, ADHD, or other mental health conditions can be challenging. While treatment often involves trying more than one medication, advances in genetic testing for psychiatry now offer an additional tool to help guide care.

What Is GeneSight® Testing?

GeneSight® is a pharmacogenomic (PGx) test that examines how your DNA may affect your response to commonly prescribed psychiatric medications. By analyzing key genetic variations, the test gives your psychiatrist information that may help identify which medications are more likely to be effective or better tolerated.

This type of genetic testing for mental health medications does not replace clinical expertise or diagnosis, but it can provide valuable insights to support a personalized treatment plan.

How the GeneSight® Process Works

  1. Easy Sample Collection – A quick, painless cheek swab. You can do this in our Manhattan office or at home with a mailed kit.
  2. Laboratory Analysis – Your sample is analyzed by the GeneSight laboratory using validated pharmacogenomic technology.
  3. Clear, Actionable Report – Results are returned to your psychiatrist in an easy-to-understand format.
  4. Personalized Care Plan – We review results alongside your history, symptoms, and goals to make more informed decisions about psychiatric medications.

Who Might Benefit from GeneSight®?

GeneSight testing may be especially helpful if you:

  • Have tried multiple antidepressants or psychiatric medications without adequate improvement.
  • Have experienced difficult side effects that limit your ability to continue treatment.
  • Want a more personalized, DNA-informed approach to your mental health care.

Important Things to Know

  • GeneSight does not diagnose conditions or guarantee one “perfect” medication. It provides genetic insights to support clinical decision-making.
  • Insurance coverage: GeneSight is covered by most major insurance plans and by Medicare. Out-of-pocket costs vary, but the majority of patients pay $330 or less. A financial assistance program is also available.
  • Testing is non-invasive and can be completed in-office or at home with a cheek swab kit.

GeneSight® Testing in New York at Greenwich Village Psychiatry

We are committed to offering evidence-based, patient-centered care. GeneSight pharmacogenomic testing is one way we tailor treatment to your unique needs and help reduce the trial-and-error of medication selection.

Frequently Asked Questions About GeneSight® Testing

Is GeneSight covered by insurance?

Yes. GeneSight is covered by most major insurance plans and by Medicare. Out-of-pocket costs depend on your plan, but most patients pay $330 or less. GeneSight also offers financial assistance for those who qualify.

Can GeneSight be done at home?

Yes. Testing can be completed in our Manhattan office or at home with a mailed cheek swab kit. Both options are quick and easy.

Does GeneSight tell me exactly which medication will work?

No. GeneSight does not predict a single “best” medication. It groups medications by potential gene–drug interactions so your psychiatrist can make more informed choices.

How long do results take?

Most results are available within a few business days after the lab receives your sample. We’ll review the report with you and discuss next steps.

What conditions can GeneSight help with?

GeneSight is most often used when treating depression, anxiety, ADHD, and related conditions where medication is part of care.

Do I need GeneSight if I’m already on medication?

It can still be useful—especially if you haven’t found adequate relief, have experienced side effects, or are considering a change in medication.

Take the Next Step

Interested in whether GeneSight genetic testing could help guide your treatment? Contact Greenwich Village Psychiatry to schedule a consultation. You can call our office or use the website contact form—our team will walk you through the process and determine if testing is appropriate for you.

At a Glance

Dr. Paul Poulakos

  • Attending Psychiatrist at Mount Sinai Beth Israel Medical Center
  • Assistant Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai
  • Past Clinical Assistant Professor of NYU Langone Medical Center
  • Learn more